RESUMO
Abrus precatorius seeds are highly toxic and are often ingested as a means of suicide in India. Hemorrhagic gastroenteritis with erosions, hemolysis, acute renal damage, hepatotoxicity with elevated liver enzymes, and seizures are common manifestations of toxicity. We report two cases of Abrus precatorius poisoning with raised intracranial pressure (ICP) and papilledema that have not been described earlier in literature. One patient recovered completely with conservative management to lower raised ICP while the other patient expired before effective treatment could be institutedd. The cases are being reported to propose the need for routine fundus examination and brain imaging in severe abrus poisoning with CNS toxicity, as early institution of treatment for cerebral edema measures may be life saving.
Assuntos
Abrus/intoxicação , Encefalopatias/etiologia , Gastroenteropatias/etiologia , Intoxicação por Plantas/etiologia , Sementes/intoxicação , Adolescente , Adulto , Encefalopatias/tratamento farmacológico , Tratamento de Emergência , Evolução Fatal , Feminino , Gastroenteropatias/tratamento farmacológico , Humanos , Papiledema/tratamento farmacológico , Papiledema/etiologia , Papiledema/fisiopatologia , Intoxicação por Plantas/tratamento farmacológico , Resultado do TratamentoRESUMO
OBJECTIVE: Glu298 Asp polymorphism of endothelial nitric oxide synthase (eNOS) gene has been recently implicated as a genetic marker for coronary artery disease (CAD) in some studies. There is no information on the prevalence of this polymorphism and its relationship with CAD in south Indian population. METHODS: A case control study was performed for the determination of the influence of Glu298 Asp polymorphism of eNOS gene in Tamilian population of south India. The study subjects comprised of 100 angiographically proven CAD patients and 100 age- and sex-matched volunteers asymptomatic for CAD, with a low coronary risk score. Genotyping of the eNOS gene was done by the polymerase chain reaction-restriction fragment length polymorphism (PCR RFLP) method. RESULTS: The genotype distribution was not significantly different between CAD (GG; 72, GT; 26, TT; 2) and control subjects (GG; 79, GT; 18, TT; 3). The corresponding allele frequencies were G 0.85, T 0.15 and G 0.88, T 0.12, respectively. The odds ratio for the association of CAD with the Asp variant failed to achieve statistical significance (OR = 0.66; 95% CI: 0.11-4.04, P = 1.0). CONCLUSION: No significant association was observed between the Glu298 Asp polymorphism and CAD in this population group.
Assuntos
Doença da Artéria Coronariana/genética , Vasos Coronários/patologia , Óxido Nítrico Sintase Tipo III/genética , Alelos , Estudos de Casos e Controles , Intervalos de Confiança , Doença da Artéria Coronariana/epidemiologia , Feminino , Marcadores Genéticos , Genótipo , Humanos , Índia/epidemiologia , Masculino , Pessoa de Meia-Idade , Razão de Chances , Polimorfismo Genético , Prevalência , Medição de RiscoRESUMO
We present the case of a 35-year-old woman presenting with the rare combination of scleroderma and ischemic heart disease. Her ECG suggested old inferior wall myocardial infarction. Coronary angiography revealed significant coronary artery disease.
